Thursday, April 11, 2013

Galaxy Note 8.0 coming to the US on April 11th for $400

Galaxy Note 80 coming to the US on April 11th for $400

If you want a (semi) pocketable S Pen experience, well, then the 5.5-inch Galaxy Note II is the device for you. If you want something more akin to carrying around a digital legal pad, there's the well proportioned Note 10.1. But if one note is too small for you, and the other too big, then maybe the Note 8.0 is just right. The mid-sized tablet, announced at MWC, is finally hitting American shores on April 11th for $400. Under the hood are the same powerful internals we got a good look at in Barcelona, including the 2GB of RAM and 1.6GHz quad-core processor. But, sadly, Samsung removed the cellular radios for the US variant -- which means this slate won't double as a comically large phone. Well, at least the lack of HSPA+ should mean that the 4,600 mAh battery should last a little bit longer. You'll be able to pick up the Galaxy Note 8.0 in just a few days from all usual suspects (Best Buy, Amazon, Newegg, and so on). If you need a proper reminder of all its various specs and features, check out the preview and the PR after the break.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/Ih00_XdGtgM/

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Wednesday, April 10, 2013

Anatomy of another NRA victory

Most Americans support tougher gun control measures. Too bad the gun lobby has so many politicians in its pocket

There's no denying it: The National Rifle Association has won ? again. Even though more than 3,000 Americans have died via gun violence?since 20 children and 6 adults were murdered at Sandy Hook Elementary in December, the NRA has somehow managed to triumph. The victims' families and gun control advocates have lost. Forget an assault weapons ban?? or any other serious gun regulation. It's not happening.?

The Washington Post notes that not only have the NRA's tactics cowed politicians and beaten back substantive national gun control efforts, but in some instances, they've actually led to moves to make guns easier to get.?Meanwhile, at least a dozen GOP senators have signed on to Kentucky Sen. Rand Paul's call to filibuster any gun control measure.

SEE MORE: Poll: Americans pretty clueless about what gun laws already exist

This is just one more issue where polls show Republicans?at odds with mainstream America.?A Morning Joe/Marist?poll found six in 10 respondents?? including 83 percent of Democrats, 43 percent of gun owners, and 37 percent of Republicans ? believe that the laws covering gun sales should be stricter.

Here's the problem:?The NRA has a lot of money, and?NRA donations go overwhelmingly to Republicans. They are unsurprisingly blocking tougher gun control.

SEE MORE: Is Marco Rubio stalling on immigration reform?

Writes The Daily Beast's Michael Tomasky: "I have never seen a situation in which a Congress, terrified of a particular lobby, has behaved in such open contempt of?American public opinion?as it's doing now on guns."?

The brutal truth is that the 20 little kids who perished in Newtown in a terrifying massacre involving 154 rounds fired in 5 minutes was NOT enough to significantly move the dial on gun control. These kids are now (more) collateral damage in the decades-long political gun-control ballet involving lobbying money and the way American politics truly functions. Poll numbers alone won't enact change.

SEE MORE: Sorry, steak-lovers: Even lean red meat may cause heart disease

Political scientist Jonathan Bernstein writes: "See, the problem here is equating '90 percent in the polls'" ? polls show that 9 in 10 Americans support universal background checks ? "with 'calling for change.' Sure, 90 percent of citizens or registered voters... will answer in the affirmative if they're asked about this policy. But that's not all the same as 'calling for change.'...Action works. 'Public opinion' is barely real... At best, public opinion as such is passive. And in politics, passive doesn't get results."

We know the pattern: (1) a massacre; (2) intial shock, media saturation, and noble-sounding rhetoric from politicians about change; (3) statements of regret or lawyerly type statements with loophopes from the gun lobby; (4) mobilization of the NRA and ideological echo chambers to go on the attack and wield political clout.?

SEE MORE: Obama consolidates power in second term

I was one of many staffers on The San Diego Union who covered James Huberty's July 18, 1984, San Ysidro McDonald's massacre. Huberty fired 250 rounds and killed 21 people from 8 months to 74 years old. He wounded 19 more before being shot dead by a sniper. There was outrage in the immediate aftermath. Then reform efforts failed.

For real gun control to triumph, it must get through a huge maze of institutional, political, and ideological media obstacle courses.?

SEE MORE: Is gridlock starting to ease?

Gun control advocate Matt Bennett told the Washington Post that if there was a secret ballot on gun control it would "pass overwhelmingly, because from a substantive point of view most of these senators understand that this is the right thing to do." Politics hold them back.

President Obama recently expressed dismay over these sad truths, and reminded America about the first-graders butchered in Newtown: "The entire country was shocked, and the entire country pledged we would do something about it and that this time would be different," he declared. "Shame on us if we've forgotten. I haven't forgotten those kids. Shame on us if we've forgotten."

SEE MORE: Huntsman etches a new conservative brand

Shame on us, indeed. Because in American power politics ? as the long battle for gun control stymied by big money, cowardice, and lack of organized-for-action public outrage shows ? there is no change. Just more and more cases of collateral damage.?

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Source: http://news.yahoo.com/nra-won-062400047.html

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Kindergarten Student Suspended for Distracting, Distruptive Haircut

Source: http://www.thehollywoodgossip.com/2013/04/kindergarten-student-suspended-for-distracting-distruptive-hairc/

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Newtown victims' families in Washington, quietly pushing gun control

By Deborah Zabarenko

WASHINGTON (Reuters) - Family members of the Newtown school shooting victims flew into Washington on Air Force One to press for gun-control legislation, but kept a low profile as they held private meetings with senators on Tuesday.

After coming to the capital aboard the presidential plane on Monday evening, the families had breakfast with Vice President Joe Biden. He said after the two-hour meeting, "I wish the members of Congress had been able to eavesdrop on the discussion in my home today."

The 11 family members stayed largely out of sight on the first of three days of lobbying in Washington, maintaining that private meetings with lawmakers would serve their cause better than grandstanding. They did hold a conference call with reporters.

"We're just private citizens who are now part of a club we never wanted to be in," said Bill Sherlach, whose wife Mary was the school psychologist at Sandy Hook Elementary School, one of six adults and 20 children killed in the December 14 attack.

"We're not up on all the political wranglings that go on," Sherlach said. "We're just the ordinary public, coming to the people that we elected to the offices nationwide and try to bring a program to the table that will be wide-ranging."

The shooting in the small Connecticut town horrified the country and prompted President Barack Obama to seek ways to prevent such massacres, including gun control. But his administration has struggled to gain support for legislation amid strong opposition from the powerful National Rifle Association.

The Newtown families are pushing for background checks to prevent criminals and the mentally ill from buying guns, and they want a provision to limit the capacity of gun magazines.

KEEPING POLITICS TO A MINIMUM

The families planned a series of private meetings with Democratic and Republican senators, but declined to name the lawmakers, except for Sen. Charles Grassley, an Iowa Republican who they said had agreed to be identified.

They said no senator had declined to meet with them. Senator Mark Pryor, an Arkansas Democrat who faces a tough re-election race next year in a state where gun control faces stiff opposition, said his office would try to schedule a meeting.

Making the Capitol Hill meetings private would keep politics to a minimum, the families said.

Tim Makris, executive director of the advocacy group Sandy Hook Promise, said private meetings let legislators open up in a way public meetings don't.

"When it's public, unfortunately at times it can turn political and then nothing happens," he said.

The Senate is expected to hold a preliminary, test vote on a gun-control measure on Thursday, but Democratic Leader Harry Reid said the bill may not get past Republican procedural hurdles. Republican Leader Mitch McConnell said there was no bipartisan support for the effort.

Obama's proposals include expanded background checks for gun buyers, a ban on assault weapons and high-capacity ammunition magazines.

Makris said the Sandy Hook shooter brought 30-bullet magazines to the school and left smaller magazines at home.

"We know when the shooter stopped to reload, he made it possible for 11 children to escape," Makris said. "And we're left to wonder, if he had carried smaller magazines, and been forced to reload up to three times more ... would more children be alive?"

The group sought to present a human face to lawmakers.

Asked what the group could bring to the debate what other gun-control advocates could not, Mark Barden, whose 7-year-old son Daniel was killed in the shooting, told the conference call:

"Lots of people can discuss the issues from an intellectual perspective, but we bring a personal perspective."

(Reporting by Deborah Zabarenko; Additional reporting by Roberta Rampton and Richard Cowan; Editing by Frances Kerry)

Source: http://news.yahoo.com/newtown-victims-families-washington-quietly-pushing-gun-control-233101254.html

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Quirky Black Girls: Finding Poems: A Creative Writing Retreat Series ...

Finding Poems: A Creative Writing Retreat Series by Alexis Pauline Gumbs*
alexispaulinephoto?This set of 6 one-day community writing retreats over a six month period is designed to offer writers at all levels an opportunity to find the poems speaking to them everywhere and to deepen their poetic practice by drawing inspiration from black feminist poets.? Each retreat will be all day on a Saturday in Durham, NC and will include meals, inspiration, nerdy contextualization and loving support from an exuberant educator who has been creating transformative writing space for over 15 years.

1. The Lorde Concordance and Oracle Building (inspired by Audre Lorde)
This first retreat is about queerly finding poems in the alphabet.? Drawing on Alexis?s Lorde Concordance practice, this retreat consists of activities that re-alphabetize poems in order to find new messages, and sometimes the same messages and some times silliness.?? Every poem we love is a possible oracle.? Each participant should bring a favorite poem.

pic-eshockley2. ?A Thousand Words (inspired by Evie Shockley)
In her Half-Red Sea Evie Shockley has a powerful thousand word poem that performs the never equal relationship between words and imagery.? In this retreat drawing on our own photographs and some chosen by the facilitator we will make our own thousand word poems in conversation with an image that we find meaningful, impossible, sacred or something.
alice+walker+young+standing3. Walking Into Poems (inspired by Alice Walker)
Alice Walker writes everyday planetary poems. ?As one of the most explicitly political nature poets ever, the simplicity of her poems has a lot to teach any poet about the relationship between writing about nature, as such, and writing about the healing potential ?human nature.?? This retreat will consist of a series of guided walks searching for everyday poems offered by the planet.

hsp4. Poems as Architecture (inspired by June Jordan)
Did you know that acclaimed black feminist poet June Jordan was an architect??? Not only that, she won the Prix de Rome in architecture in the 1970s.??? This retreat asks us to find the poems in the built environment around us in conversation with the poems that June Jordan wrote while in Rome (some of her less studied work).? For more by Alexis on June Jordan and the poetics of architecture see: http://pluraletantum.com/2012/03/21/june-jordan-and-a-black-feminist-poetics-of-architecture-site-1/
220px-For_Cornelia5.? Lucille Clifton and the Poems of our Past Lives
Many people do not know that the great poet Lucille Clifton was also in communication with other worlds.? In her archived papers there are several proposed manuscripts of books that talk about her communication with the dead. Based on Lucille Clifton?s dream poems and past life poems this retreat is about looking for the poems in our own dreams, memories and inklings and maybe even our conversations with folks who are no longer on this plane.
5412-310-2176. Finding Poems Underwater (inspired by Marlene Nourbese Philip)
Drawing on excerpts from Marlene Nourbese Philip?s epic, orchestral, heteroglossaic book length poem Zong, written in honor of captured Africans who were intentionally drowned off the coast of Jamaica so a slaver could collect insurance money for their deaths, this retreat is about finding poems underwater, in deep inner space, behind trauma and the unsayable.

Logistics:
In order to make this rare and priceless opportunity accessible and sustainable it will be community funded.? All workshops will take place in Durham, NC. ? Community members interested in participating can help with a process through which Eternal Summer of the Black Feminist Mind gains new monthly sustainers of 750 per month (15 sustainers at $50 each, 150 sustainers at $5 or any combination).? People who participate in the sustainer-raiser have first priority in any or all of the 6 retreats. Dates will be set after the success of the community sustainer raiser.? If there is space in any of the retreats community members who have not participated in that process can sign up with a deposit two weeks in advance of the retreat and an offering of something they can afford.?? If you would like to be part of the sustainer/raiser project email writerwk1 at mac dot com.

ALEXIS PAULINE GUMBS is a queer black troublemaker, a black feminist love evangelist, a prayer poet priestess and has a PhD in English, African and African-American Studies and Women and Gender Studies from Duke University. ?Alexis was the first scholar to research in the Audre Lorde Papers at Spelman College, the June Jordan Papers at Harvard University and the Lucille Clifton Papers at Emory University and is currently on tour with her interactive oracle project "The Lorde Concordance" a series of ritual mobilizing the life and work of Audre Lorde as a dynamic sacred text. Alexis has also published widely on Caribbean Women's Literature with a special interest in Dionne Brand. Her scholarly work is published in Obsidian, Symbiosis, Macomere, The Routledge Companion to Anglophone Literature, SIGNS, Feminist Collections, The Black Imagination, Mothering and Hip Hop Culture, The Business of Black Power and more. Alexis is the author of an acclaimed collection of poems 101 Things That Are Not True About the Most Famous Black Women Alive and poetic work published in Kweli, Vinyl, Backbone, Everyday Genius, Turning Wheel, UNFold, Makeshift and more. She has several books in progress including a book of poems Good Hair Gone Forever, a scholarly monograph on diaspora and the maternal and an educational resource called the School of Our Lorde. She is also the co-editor of a forthcoming edited collection on legacies of radical mothering called This Bridge Called My Baby.?

Alexis has been living in Durham, NC for almost a decade and has been transformed and enriched by holistic organizing to end gendered violence and to replace it with sustaining transformative love.? Locally she is a founding member of UBUNTU a women of color and survivor-led coalition to end sexual violence, of the Earthseed Collective a black and brown land and spirit reclamation project and the Warrior Healers Organizing Trust, a community accountable foundation practicing organic reparations and transforming blood money into blood relations.? Nationally Alexis is co-founder of the Mobile Homecoming Project, an experiential archive project amplifying generations of black LGBTQ brilliance, and intergalactically she is the instigator of the Eternal Summer of the Black Feminist Mind, a multi-media all ages community school based in the wisdom of black feminist literary practice.?? Alexis is also a literary scholar with a PhD in English, Africana Studies and Women's Studies from Duke University and a widely published poet and essayist. ? Alexis likes to pray by walking, dancing,?remembering poems and talking and playing with loved ones.
Alexis was named one of UTNE Reader's 50 Visionaries Transforming the World in 2009, was awarded a Too Sexy for 501-C3 trophy in 2011 and is one of the Advocate's top 40 under 40 features in 2012.
*This idea was made possible by conversations with two of my favorite poets: Samiya Bashir and Faith Holseart.

Source: http://quirkyblackgirls.blogspot.com/2013/04/finding-poems-creative-writing-retreat.html

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Why going green is good chemistry

Apr. 8, 2013 ? Shaken, not stirred, is the essence of new research that's showing promise in creating the chemical reactions necessary for industries such as pharmaceutical companies, but eliminating the resulting waste from traditional methods.

James Mack, a University of Cincinnati associate professor of chemistry, will present this research into greener chemistry on April 9, at the annual meeting of the American Chemical Society in New Orleans.

Instead of using solutions to create chemical reactions needed to manufacture products such as detergents, plastics and pharmaceuticals, Mack is using a physical catalyst -- high-speed ball-milling -- to force chemicals to come together to create these reactions. The mechanochemistry not only eliminates waste, but also is showing more success than liquids at forcing chemical reactions.

Traditional methods -- dating back thousands of years -- involve using solutions to speed up chemical reactions that are used to make products that we use every day. However, the leftover waste or solvents can often be a volatile compound, explains Mack.

Disposal and recycling is also becoming a growing and more costly challenge for companies as they follow increasing federal regulations to protect the environment. "The solvents comprise the large majority of chemicals that are handled, but the solvent doesn't do anything but serve as a mixing vehicle. For example, for every gram of pharmaceutical drug that is generated, 15 to 20 kilograms of solvent waste is generated in that process," Mack says.

"Mechanochemistry can develop new reactions that we haven't seen before, saving on waste and developing new science," Mack says.

Mack also will report on how he has used a metal reactor vial to create chemical reactions, allowing recovery of the catalyst used to make the reaction, which usually can't be achieved by using solutions. He also is exploring efforts at using natural chiral agents -- agents that are non-superimposable, mirror images of each other -- to successfully mix chemicals and eliminate waste such as oil.

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The above story is reprinted from materials provided by University of Cincinnati. The original article was written by Dawn Fuller.

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Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_technology/~3/l5Ubmw1QsCU/130408123302.htm

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Tuesday, April 9, 2013

Fitness after 65 is no one-size-fits-all endeavor

By Dorene Internicola

NEW YORK (Reuters) - America's ageing population is posing special challenges, fitness experts say, because it is difficult to design effective workout routines for people with such a wide range of abilities.

For one 70-year-old, the goal may be to run a marathon, for another it's getting out of a chair.

"If you are teaching 10-year-olds, it's perfectly reasonable to do an activity that everybody would participate in," said Dr. Wojtek Chodzko-Zajko, an expert on aging with the American College of Sports Medicine.

But 20 80-year-olds could be as different as chalk and cheese."

Some baby boomer could be athletic, he explained, while others would be unable to get out of bed.

There are now more Americans age 65 and older than at any other time in U.S. history, according to Census Bureau figures. Some 40 million people age 65 and over lived in the United States in 2010, accounting for 13 percent of the total population. The older population grew from 3 million in 1900 to 40 million in 2010.

Older adults should be doing aerobic activity to help maintain body weight, strengthening exercises to develop and maintain muscle mass and some type of flexibility training, according to Dr. James Graves, Dean of the College of Health at the University of Utah.

Physical activity can reduce the risk of diseases such as diabetes, hypertension and osteoporosis, he said, as well as improve the quality of life by maintaining functional capacity, such as the ability to climb stairs, open doors, and carry groceries.

"A very healthy 70-year-old can safely participate in high-intensity activity while a frail 60-year-old needs to lower the intensity," said Graves. "My recommendation is to work with a personal trainer or group leader who has knowledge and qualifications to work with the elderly."

Mary Ann Wilson is the creator and host of the "Sit and Be Fit," a senior fitness program that has aired on U.S. public television since 1987.

The majority of her viewers are women over 65. For that population, she said, the goal of exercise is health and well-being, not physical prowess.

"Gravity has been working on them for 70 years," said Wilson, a registered nurse who specialized in geriatrics. "Gravity is not our friend after many years of pulling our heads, shoulders and upper torsos forward and down."

The 30-minute class includes warm-up, circulation and strength segments, a finger segment (for stiffness), standing for balance, and final relaxation.

Posture, breathing, balance, cognitive functioning and reaction time are among the most important?and neglected?components of elder fitness, she said.

"Focusing on gait is really important because as we age our gait changes," said Wilson.

Karen Peterson, author of "Move with Balance: Healthy Aging Activities for Brain and Body," stresses a mind-body approach in workouts with seniors.

"In our society it seems people don't really like to do things unless they're good at it already," said Peterson, a kinesiologist based in Maui. "But what the brain likes is to be challenged."

Her exercises include tossing a bean bag to improve reaction time, walking a figure-eight pattern for balance, as well as eye stretches, jaw relaxers, childhood games and cognitive challenges to keep body and mind alert.

"We take balance exercises and add conversation or math problems," she said. "The concept is to always progress, always get more challenging."

To tackle the isolation and diversity of the older population, Peterson initiated a mentoring program in which the fitter seniors work with the frailer.

"Some partners will become friends," she said. "They'll get really turned on."

Experts agree that it's never too late to do something. "Exercise is effective even in the most frail individual," Wilson said. "If they can wiggle their toes, they can exercise."

(Editing by Patricia Reaney and Sandra Maler)

Source: http://news.yahoo.com/fitness-65-no-one-size-fits-endeavor-103841481.html

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Arrested Development Quotes: Best of the Best!

Source: http://www.thehollywoodgossip.com/2013/04/arrested-development-quotes-best-of-the-best/

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Monday, April 8, 2013

G-Technology shows off a Thunderbolt-powered dock with dual hard drive bays

G-Technology shows off a Thunderbolt-powered dock with dual hard drive bays

We have a feeling 4K is going to be a major theme at this year's NAB, which also means we'll be seeing a good deal of hardware that can actually handle such high-res content. Mostly, we're talking pro cameras and the like, but at least one company will be showing off some professional-grade hard drives -- after all, you're gonna need a solid storage solution to process those supersize files, right? G-Technology just introduced the "Evolution" family of products, the centerpiece of which is the G-Dock ev, a mini-tower with two hard drive modules and dual Thunderbolt connections. What you put in those hard drive slots is up to you: the company is offering both a 9.5mm 7,200RPM drive (rated for 136 MB/s transfers) and a beefier 15mm cartridge promising 250 MB/s. Once you choose your drives, you can arrange them in a RAID 1 configuration if redundancy is important, or RAID 0 for maximum speed.

What's more, each of the drives has a USB 3.0 socket on board, so if you needed to you could hand it to someone else in your office and let them grab whatever data they needed off the HDD. In any case, the dock will come standard with two 1TB, 9.5mm drives -- look for it next month, priced at $750 for the bundle. If you later need some additional cartridges, the 9.3mm G-Drive ev will cost either $150 or $200, depending on whether you want 500 gigs or a full terabyte. The bigger 15mm G-Drive ev Plus will go for $350 (it'll be sold with 1TB only). Lastly, G-Technology also announced the G-Drive Pro with a Thunderbolt port and claimed transfer speeds of 480 MB/s. That'll ship this summer for either $700 or $850, depending on whether you want 2TB or 4GB of storage. All that's in the PR after the break, along with an endorsement from Vincent Laforet himself. Must be good, right?

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/R79LSsPR6aA/

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Portugal to cut spending after court ruling

LISBON (Reuters) - Portugal's government will cut spending to meet targets agreed with its lenders after a court overturned key austerity measures, Prime Minister Pedro Passos Coelho said on Sunday.

Passos Coelho said in a televised address Friday's Constitutional Court ruling posed "serious obstacles and risks" this year and next, but reaffirmed his commitment to the fiscal and economic adjustment program under an EU/IMF bailout.

"The government is committed to all the objectives of the program," he said, ruling out further tax hikes but saying it was vital to avoid a second rescue and that he had told ministers to cut spending.

The court on Friday rejected four out of nine contested austerity measures in this year's budget, including cuts to holiday bonuses for pensioners and public servants and reductions in sickness leave and unemployment benefits.

Analysts expect Portugal to be able to agree replacement measures with the European Union and International Monetary Fund to make up for the court ruling, which could cost it between 900 million and 1.3 billion euros.

The entire package of austerity measures included in the 2013 budget is worth about 5 billion euros. The largest tax hikes in living memory were mostly upheld by the court.

The court's decision came before an informal meeting of euro zone finance ministers this week in Dublin expected to approve extensions of rescue loan maturities for Portugal and Ireland.

Passos Coelho acknowledged that the ruling weakened Portugal's stance at the meeting, but said he told Finance Minister Vitor Gaspar to do all he could to protect the country's interests there and achieve an extension.

The government says the extension is essential for Lisbon's successful exit from the bailout program in 2014.

Lisbon has to cut the budget deficit to 5.5 percent of gross domestic product this year from 6.4 percent in 2012, when it missed the goal but was still lauded by lenders for its efforts. The lenders have eased Portugal's deficit goals twice since the rescue was agreed, recognizing consolidation efforts.

Portugal returned to the bond market for the first time since its 2011 bailout in January, selling debt due in 2017, and has been preparing a longer-maturity bond issue. Analysts say the court ruling may now delay the new issue.

(Reporting by Andrei Khalip and Sergio Goncalves; Editing by Jason Webb)

Source: http://news.yahoo.com/portugal-government-sticks-bailout-goals-despite-court-ruling-182103272.html

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Sunday, April 7, 2013

Screening blood samples for cancer-driving mutations more comprehensive than analyzing traditional tumor biopsy

Apr. 6, 2013 ? Researchers using a tool called BEAMing technology, which can detect cancer-driving gene mutations in patients' blood samples, were able to identify oncogenic mutations associated with distinct responses to therapies used to treat patients with gastrointestinal stromal tumors (GIST), according to a researcher who presented the data at the AACR Annual Meeting 2013, held in Washington D.C., April 6-10.

Data from a subanalysis of the phase III GIST-Regorafenib In Progressive Disease (GRID) trial indicated that this blood-based screening technology may provide physicians with a real-time, comprehensive picture of a patient's tumor mutations, according to George D. Demetri, M.D., director of the Ludwig Center at Dana-Farber Cancer Institute and Harvard Medical School in Boston, Mass.

"Our results show that it is possible to sum the total of all of the heterogeneity in a cancer and get a clear picture of the entire tumor burden, using a simple blood sample," Demetri said.

In this era of targeted cancer therapies, the goal is to focus cancer treatments on a specific molecular target. However, as researchers discover more about cancers and their heterogeneity, they are finding many patients have anywhere from one to dozens of different mutations in their tumors.

"It is a real issue that when you do a biopsy on one tumor, and then biopsy a different tumor in that same patient a few inches away or on the other side of the body, you may get a different answer when you do the molecular analysis," Demetri said. "With this blood test, you get a robust summary statement about all the different mutations present across the different tumors in the body. I believe this testing technology has promise to become a standard part of care in the next five to 10 years."

Data from the main analysis of the phase III GRID study showed that the molecularly targeted drug regorafenib significantly improved progression-free survival compared with placebo for patients with GIST. The researchers hope these results will ultimately lead to the drug's approval by the U.S. Food and Drug Administration (FDA), according to Demetri. The drug is intended to treat patients with advanced GIST whose disease has failed to be controlled by the only two other FDA-approved therapies for GIST, imatinib and sunitinib (Sutent).

Demetri and colleagues conducted an exploratory analysis on patients in the GRID study to assess GIST genotypes. They isolated DNA from archival tumor tissue, which was then analyzed for mutations in two genes, KIT and PDGFRA, which generate the cancer-driving proteins that are the targets of imatinib, sunitinib and regorafenib. The researchers believed that primary mutations would be detectable using traditional analysis, but that those mutations that developed after treatment with imatinib and sunitinib would not be detectable. They then took blood samples drawn at study entry after failure of both imatinib and sunitinib, and analyzed them for mutations via BEAMing technology.

Mutations in the KIT gene were detected in 60 percent of the blood samples compared with 65 percent of the tumor tissue samples. However, when focusing their analysis on secondary KIT mutations, which are the mutations that drive resistance to targeted therapies like imatinib and sunitinib, the researchers found mutations in 48 percent of blood samples compared with only 12 percent of tissue samples. In addition, nearly half of blood samples in which secondary KIT mutations were found harbored multiple secondary mutations.

Importantly, regorafenib was clinically active compared with placebo in patients with secondary KIT mutations.

According to Demetri, the results show a clear association between the presence of different cancer-driving gene mutations in patients' blood samples and clinical outcomes.

"By using this technology, we hope to develop the most rational drug combinations and better tests to match patients with the most effective therapies going forward," Demetri said.

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The above story is reprinted from materials provided by American Association for Cancer Research (AACR).

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/F_Xmn3nCydE/130407090631.htm

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Only weeks after amputation, combat vet swoops slopes with Sochi dreams

U.S. Department of Veteran Affairs

Carlos Figueroa monoskis in Aspen Snowmass on Thursday as part of a VA sports clinic for disabled veterans.

By Bill Briggs, NBC News contributor

An Iraq war veteran who yearns to snowboard next March at the Sochi Paralympics recently told a priest he would give his left leg to compete for his country. And then, he did.

Six weeks ago, retired Army Sgt. Carlos Figueroa allowed a surgeon to amputate below his left knee ? 10 years after an IED blast rendered the limb nearly useless. The decision was surprisingly simple, he said, because it sliced away a decade of mounting pain. Yet he also acknowledged: ?I did give it up because I want to get into the Paralympics.?

?When I went in, my doctor asked me: ?What?s your biggest goal?? I told him: ?Be on my board within three months.? He just said, ?Dude, most people aren?t walking within three months,? ? Figueroa recalled.?

Walking will come. What he can do ? already ? is carve down a mountain, the lone place Figueroa, 34, feels at peace: ?Up there, I?m no different from anybody. No PTSD. I?m at my happiest.? On Thursday, Figueroa beamed while manhandling an Aspen, Colo., slope atop a monoski at a sports clinic for disabled veterans. As a familiar, cool breeze brushed his face, he also dreamed?about racing in Russia.


?My love for snowboarding is about loss, the loss of what I had in the military, where you?re used to being on the move, on patrols, on raids. That?s how I treat my races. The moment that gate drops, it?s like the door opening on a raid. I go full blast. I?m able to get something back that I felt was taken away. That rush. I love it.?

U.S. Department of Veteran Affairs

"Up there, I'm no different from anybody. No PTSD. I'm at my happiest," said Carlos Figueroa of the feeling of carving down slopes.

The wars in Iraq and Afghanistan have borne a bittersweet byproduct: scores of American Paralympic hopefuls. The Sochi Paralympics, to be held just after the 2014 Winter Games in that city, marks the inaugural Paralympic snowboarding event for disabled athletes. The U.S. men?s Paralympic snowboarding squad will consist of five members.

'Slim chance'
Figueroa (and those close to him) knows he?s the longest of long shots. His own coach, Mike Shea, estimates he took two years to, literally, make the leap from his own leg amputation to landing jumps. The raw nerve endings in an amputated limb must become desensitized to the harsh pounding. When the board hits the snow, the stump pushes into the prosthetic leg, ?sending chills up your spine,? Shea said. ?It doesn?t feel good.?

Then there?s the calendar. If Figueroa is indeed back on his board by autumn, he?ll have a limited number of sanctioned races ? beginning in January 2014 ? to rack up enough points to rank among the top five American men. And the U.S. Paralympic snowboarders, including Shea, compose the world?s deepest talent pool in that sport. The roster likely will be named in February.

?It?s a slim chance, a super, super small window,? Figueroa said, ?but we?re still going to push.?

He needs only a sliver of possibility to kindle his hope ? or better yet, someone telling him he can?t. He certainly doesn?t need two legs.

The Feb. 15 amputation came 10 years after a bomb detonated beneath his armored vehicle, ejecting him through an open roof hatch. A decade spent lugging a useless left limb (with no heel), suffering increasing back and knee pain, instantly convinced him to say ?Let?s do it,? when an orthopedic surgeon in San Diego suggested, ?Let?s cut.? He was done, he said, wasting another day ?in a bubble? due to his injury, calling the operation ?liberating.?

'Go fast and have fun'
Nobody who has heard that account is betting against Figueroa.

?With any military athlete, you can definitely see that sense of pride and determination above and beyond what you see with other athletes. Part of it is just a chance to represent their county again,? said Kevin Jardine, high performance director of Parlaympic alpine skiing and snowboarding for the U.S. Olympic Committee. ?They?re willing to sacrifice a lot.?

Added Shea, who lost his leg in a 2002 wake-boarding accident: ?Anything you tell Carlos, he?ll get it done. He always seems to find a way. He has no fear up there. He has passion. And I?ve learned from him the smiling gets you a long way in life.?

This week at the National Disabled Veterans Winter Sports Clinic in Aspen, organized by the Department of Veterans Affairs, Figueroa has been tempted to grab a board and shred. This is his fourth year attending. As a testament to his disregard for other people?s timelines, he couldn?t even stand on a snowboard four years ago due to his injury, yet he competed in a World Cup event for disabled snowboarders not long after that.

Until his prosthetic leg arrives, he?ll stick to monoskiing, during which he sits in a ?bucket? atop one ski, using his arms to hold smaller, balancing skis.

?The first run, I took it slow. After that, I opened it up,? Figueroa said. ?I just want to go fast and have fun.?

When the instructor noticed his raw speed, he warned Figueroa: ?You do realize if you go down, you may peel off half your face.?

Figueroa simply grinned: ?That?s alright.?

On the 10th anniversary of the war in Iraq, a special group of people in Vail, Colo., are also marking the tenth anniversary of their unique program designed to help war amputees regain independence through skiing. NBC's Kevin Tibbles reports.

Related:?

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/2a683190/l/0Lusnews0Bnbcnews0N0C0Inews0C20A130C0A40C0A60C175898670Eonly0Eweeks0Eafter0Eamputation0Ecombat0Evet0Eswoops0Eslopes0Ewith0Esochi0Edreams0Dlite/story01.htm

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Two Energy Revolutions Vie Across the Atlantic

german energy policyA front-page article in the Washington Post reported?on the trend of energy-related investments in the US by European companies.??This is another aspect of the competing energy revolutions I mentioned a few weeks ago,?in my comments on President Obama's State of the Union speech.? Germany's 2000 Renewable Energy Law introduced feed-in tariffs for wind and solar power that have made that country a global leader in green energy implementation, yet it has also become increasingly apparent that this carefully planned transformation paid insufficient attention to the cost of the new energy sources it was embedding at the heart of the German economy.? The Post describes how leading German firms are looking across the Atlantic to invest where energy is cheaper, thanks to the unplanned, largely unanticipated extraction of?hydrocarbons from shale.?

The Ludwigshafen, Germany dateline of the article caught my eye immediately.? Having just returned from a family trip to California with a packet of letters I wrote to my parents during a temporary work assignment in Germany in the early 1980s, I had?only yesterday re-read the account of my visit to BASF's sprawling petrochemicals complex there.? I recall being greatly impressed by the site, which dwarfed the Los Angeles refinery at which I worked at the time. The BASF facility was part of the post-war boom--the Wirtschaftswunder--that made Germany the economic and industrial center of Europe, where it remains today two decades after reunification and a decade after relinquishing its cherished Deutchmark for the Euro.? Now the company apparently wonders whether Ludwigshafen can remain competitive in?a global market dominated by US?shale gas.

The divergence of energy prices that worries German industrialists is the result of conscious choices made by that country's government and a set of developments that occurred here largely out of sight of the US government, while its attention was focused elsewhere. In the same decade in which production from shale gas deposits in Arkansas, Louisiana, Oklahoma,?Pennsylvania and Texas--output that now sets?the price of both gas and electricity in much of the US--was gathering momentum, the German government was negotiating for more imported natural gas from?Russia, via?a pipeline built by a company?led by a former German Chancellor. ?It also set up a mechanism for?consumers of electricity to fund?the payment of up to $0.70 per kilowatt-hour that was?necessary to support?the initial?solar power installations in one of the world's?least sunny countries.

German solar tariffs have declined?significantly since then, thanks in part?to ruinous competition with China-based solar manufacturers.? However, in the?aftermath of the nuclear accident at Fukushima, the German government agreed to retire the country's nuclear power?plants, which supplied 22% of its electricity in??2010.? New solar might soon be cheaper than new nuclear capacity, but there aren't many energy sources cheaper than an existing, fully-depreciated nuclear reactor, even after allowing for waste disposal and site cleanup.? As a consequence of these policies, German managers such as those at BASF face natural gas prices that are a multiple of those here, along with the prospect of steadily rising electricity rates.? The option to offshore production must seem as obvious for them as it did for US companies in 2005, when US natural gas prices reached $10 per million BTUs.

Of course this comparison is just a snapshot in time; the competition between these two energy revolutions will likely ebb and flow for years.? However, the current energy divergence between Germany and the US should remind us?that the cost of energy remains a very important economic parameter, even in highly developed countries.? Measures that inevitably raise it are very likely to bring adverse consequences, no matter how well-intended or carefully justified they might seem.? That's worth considering here, as well, when Congress debates new energy taxes and the administration proposes new rules that could raise energy costs or constrain output.?

Authored by:

Geoffrey Styles

Geoffrey Styles is Managing Director of GSW Strategy Group, LLC, an energy and environmental strategy consulting firm. Since 2002 he has served as a consultant and advisor, helping organizations and executives address systems-level challenges. His industry experience includes 22 years at Texaco Inc., culminating in a senior position on Texaco's leadership team for strategy development, ...

See complete profile

Source: http://theenergycollective.com/geoffrey-styles/205256/two-energy-revolutions-vie-across-atlantic

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Saturday, April 6, 2013

T-Mobile USA Begins Taking Pre-Orders for iPhone 5 Ahead of April 12 Launch

Quote:

so you are basically paying for an unsubsidized phone but then bound to a two year commitment and no savings on the plans ? Why would I do this again ?

I think you missed the 2nd paragraph of the article:

"Single-line service plans for the iPhone 5 require no contract and begin at $50/month for unlimited talk, text, and data, although data is slowed to 2G speeds once the customer reaches 500 MB for the month. A $60/month plan raises the high-speed data cap to 2.5 GB, and a $70/month plan includes unlimited high-speed data."

The 24 monthly payments of $20 are installment payments for the phone IF you don't want to put out the entire $580 immediately. Also, T-Mob will unlock the phone as soon as the phone is paid off, unlike ATT.

I'm on ATT & no plan to switch to T-Mob, but based on U.S. coverage, not $. T-Mob as a carrier is meh, that is why I won't switch.

Source: http://forums.macrumors.com/showthread.php?t=1566531&goto=newpost

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US companies likely kept up steady hiring in March

This Friday, March 29, 2013, photo, shows a help wanted sign in front of a restaurant in Richmond, Va. The U.S. economy has enjoyed a four-month stretch of robust job gains, and on Friday, April 5, 2013, the government will signal whether that trend endured into March (AP Photo/Steve Helber)

This Friday, March 29, 2013, photo, shows a help wanted sign in front of a restaurant in Richmond, Va. The U.S. economy has enjoyed a four-month stretch of robust job gains, and on Friday, April 5, 2013, the government will signal whether that trend endured into March (AP Photo/Steve Helber)

(AP) ? The U.S. economy has enjoyed a four-month stretch of robust job gains, and on Friday the government will report whether that trend endured into March.

Economists generally think it did. They predict that employers added a solid 195,000 jobs, according to a survey by FactSet. That's a healthy gain, although below February's 237,000 net jobs added.

The unemployment rate is expected to remain at a four-year low of 7.7 percent.

The Labor Department will release the report at 8:30 a.m. EDT Friday.

Job gains have accelerated to an average of 205,000 per month from November through February. That's nearly double the monthly gains from last spring. The forecast figure for March would continue that trend.

Still, several subpar economic reports this week have signaled that the job market may have weakened last month. That could mean companies are worried about government spending cuts that began on March 1.

Services companies hired at a slower pace in March, according to the Institute for Supply Management, a trade group.

Payroll processor ADP said private employers added just 158,000 jobs in March, down from the survey's estimate of 237,000 jobs in February.

And on Thursday, the government said the number of people seeking unemployment benefits rose last week for the third straight time and to the highest level in four months. That could mean layoffs have increased. The government cautioned that seasonal factors may have also contributed to last week's gain.

Analysts noted that the ADP survey is not always an accurate predictor of the government's more comprehensive figures. Still, some economists lowered their forecasts for March job growth after seeing the reports. A few predict the job gains could be closer to 150,000.

Overall, economic growth likely perked up considerably in the January-March quarter after barely expanding in the final three months of last year. Most economists expect growth will top 3 percent in the first quarter. It grew only 0.4 percent in the October-December quarter.

Americans appear to have shrugged off an increase in Social Security taxes that began in January. Consumers boosted their spending in February by the most in five months.

Consumers have been aided by the Federal Reserve's efforts to keep interest rates low. That has spurred higher sales of homes and cars. Many homeowners have also refinanced their mortgages at much lower rates, freeing up more money to spend on other items.

The housing market is recovering steadily. In February, sales of previously owned homes reached the highest level in more than three years. And home prices nationwide rose by the most in seven years that month compared with the same month a year ago. Builders broke ground on new homes at the second-fastest pace in nearly five years.

Still, many economists worry that growth will slow in the spring and summer because of the $85 billion in automatic government spending cuts.

Economists expect the spending reductions will shave half a percentage point off economic growth this year. Many federal workers will experience pay cuts. And government contractors will likely cut jobs. That could also drag down overall monthly hiring.

Mark Vitner, an economist at Wells Fargo Securities, expects that the economy expanded at a 3.2 percent annual rate in the first quarter. But he forecasts growth will slow to a 2 percent pace in the second quarter, and then rebound after the impact of the government spending cuts fades.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-04-05-US-Economy/id-afe5bf900cd541ae95afbfaaef6755d9

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Colorado State University rec center makes Top 25

Sorry, Readability was unable to parse this page for content.

Source: http://www.coloradoan.com/article/20130405/NEWS01/304050021/1002/rss

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Friday, April 5, 2013

PSA: T-Mobile's iPhone 5 pre-orders start rolling today

PSA TMobile iPhone 5 preorders start rolling today

If T-Mobile's recent event cussed you into wanting one of its tweaked A1428 iPhone 5s with LTE, AWS HSPA+ and no contract strings attached, you can now order one up. Apple's flagship can be had through the carrier for $99 down and 24 payments of $20 for a total of $579 -- a snappy $70 savings over buying one directly from Cupertino. Meanwhile, T-Mo's Simple Choice plan starts at $50 per month for unlimited talk, text and 500MB of data, with an additional 2GB for $10 and unlimited 4G data for $20. Just remember that should you opt into an iPhone 5 through T-Mobile then decide to opt out of your contract, the device will stay carrier locked until you pay it off or trade it back -- unless you're willing to skirt the law, of course. Hit the source to make your reservation.

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Source: T-Mobile

Source: http://www.engadget.com/2013/04/05/psa-t-mobile-iphone-5-pre-orders-start-rolling-today/

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10 Things to See: A week of top AP photos

Here's your look at highlights from the weekly AP photo report, a gallery featuring a mix of front-page photography, the odd image you might have missed and lasting moments our editors think you should see.

This week's collection includes a three-alarm fire in New Orleans, the aftermath of a suicide car bombing in Iraq, a group of faithful men carrying a statue of Jesus in Peru and Kevin Ware writhing in pain after breaking his leg during a March Madness basketball game.

___

This gallery contains images published March 28, 2013 - April 4, 2013.

Follow AP photographers on Twitter: http://apne.ws/VyAhxg

___

See other recent AP photo galleries:

Gazans turn wood into charcoal: http://apne.ws/XRJt2j

The Final Four is set: http://apne.ws/14QhcMG

Easter Sunday around the world: http://apne.ws/14GR3zq

Good Friday around the world: http://apne.ws/16ySu1h

Images from the Hindu festival of Holi: http://apne.ws/14GRaep

___

AP10ThingsToSee Week 1: http://apne.ws/ZWiCOl

AP10ThingsToSee Week 2: http://apne.ws/ZWiJt0

AP10ThingsToSee Week 3: http://apne.ws/10USsze

AP10ThingsToSee Week 4: http://apne.ws/14Qg5N1

___

Follow AP Images on Twitter: https://twitter.com/AP_Images

Visit AP Images online: http://www.apimages.com

___

This gallery is curated by news producer Caleb Jones in New York: http://apne.ws/XS18XB

Source: http://news.yahoo.com/10-things-see-week-top-ap-photos-170136692.html

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Thursday, April 4, 2013

Airblaster Presents Board Games at Timberline Lodge - YoBeat

By admin ? Apr 3rd, 2013 ? Category: News

BOARD GAMES

Time to grab your friends, throw your wood planks in the car and head to Timberline for Airblaster?s Board Games! Prepare for an all-around good time with your buds shredding Terry?s Maximum Airtime Rhythm Section. Get ready to tweak, turn, flip and rip with your friends! Join us for the third Board Games at Timberline since it?s resurrection from the dead. First thirty entrants will receive a fun bag (a bag full of fun stuff) from all our awesome sponsors! Throw on the Hawaiian shirt, let the chest hair fly and we?ll see you at Timberline April 14th for some party
boarding!

Tagged as: Airblaster, board games, fun for the whole family, Timberline Lodge

Source: http://www.yobeat.com/2013/04/03/airblaster-presents-board-games-at-timberline-lodge/

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Scientists develop new protocol to ready induced pluripotent stem cell clinical application

Apr. 3, 2013 ? A team of New York Stem Cell Foundation (NYSCF) Research Institute scientists led by David Kahler, PhD, NYSCF Director of Laboratory Automation, have developed a new way to generate induced pluripotent stem (iPS) cell lines from human fibroblasts, acquired from both healthy and diseased donors. Reported in PLOS ONE, this cell-sorting method consistently selects the highest quality, standardized iPS cells, representing a major step forward for drug discovery and the development of cell therapies.

Employing a breakthrough method developed by 2012 Nobel laureate Shinya Yamanaka, MD, PhD, adult cells are "reprogrammed" or reverted to an embryonic-like state, commonly through viral infection. Reprogramming is a dynamic process, resulting in a mixture of fully reprogrammed iPS cells, partially reprogrammed cells, and residual adult cells. Previous protocols to select promising fully reprogrammed cells rely primarily on judging stem cell colonies by eye through a microscope.

Cell colonies selected by qualitative measures could include partially reprogrammed cells, a major concern for clinical applications of cell therapies because these cells could become any other cell type in a patient following transplantation. Additionally for drug efficacy assays and toxicity investigations on iPS cells, heterogeneous cell populations can mar the response of representative iPS cell lines.

The NYSCF scientists developed a quantitative protocol, optimized over three and a half years, in order to consistently harvest early-reprogrammed cells. Using fluorescence activated cell sorting (FACS), fully reprogrammed cells were identified by two specific proteins, or pluripotency markers. The group then looked at third marker that is expressed by partially reprogrammed or adult cells, and they then negatively selected against these cells to obtain only fully reprogrammed cells.

"To date, this protocol has enabled our group to derive (and characterize over) 228 individual iPS cell lines, representing one of the largest collections derived in a single lab," said Dr. Kahler. "This standardized method means that these iPS cells can be compared to one another, an essential step for the use in drug screens and the development of cell therapies."

This process of selecting stem cell colonies provides the basis for a new technology developed by NYSCF, The NYSCF Global Stem Cell Array (Array), a fully automated, robotic platform to generate cell lines in parallel. Currently underway at the NYSCF Laboratory, the Array reprograms thousands of healthy donors' and diseased patients' skin and/or blood samples into iPS cell lines. Sorting and characterizing cells at an early stage of reprogramming allows efficient development of iPS cell clones and derivation of adult cell types.

"We are enthusiastic about the promise this protocol holds to the field. As stem cells move towards the clinic, Dr. Kahler's work is a critical step to ensure safe, effective treatments for everyone," said Susan L. Solomon, CEO of NYSCF.

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The above story is reprinted from materials provided by New York Stem Cell Foundation.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. David J. Kahler, Faizzan S. Ahmad, Anita Ritz, Haiqing Hua, Dorota N. Moroziewicz, Andrew A. Sproul, Carmen R. Dusenberry, Linshan Shang, Daniel Paull, Matthew Zimmer, Keren A. Weiss, Dieter Egli, Scott A. Noggle. Improved Methods for Reprogramming Human Dermal Fibroblasts Using Fluorescence Activated Cell Sorting. PLoS ONE, 2013; 8 (3): e59867 DOI: 10.1371/journal.pone.0059867

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/FbMSpTy2wGQ/130403092655.htm

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Holy Crap, Is This Mark Zuckerberg's Embarrassing Childhood Angelfire Website?

The word on the interwebs today is that this 1999 Angelfire page belongs to one Mark Zuckerberg. Yes, that Mark Zuckerberg, which means this could be the very first website that the hoody that made Facebook ever created. If true, it's a time machine into the 15-year-old brain of the most powerful man on the Internet. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/ABRCjSjpcSs/holy-crap-is-this-mark-zuckerbergs-childhood-angelfire-website

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Full Frame 2013: Four fine documentaries by Durham filmmakers ...

Full Frame began its life late last century, conceived at Duke's Center for Documentary Studies. In the ensuing years, the festival grew to international renown; meanwhile, the city of Durham became a home base for filmmakers themselves.

This year, several Durham filmmakers have finished work in the festival. The sole feature filmmaker, Elisabeth Haviland James, is also the newest arrival to the Bull City. In 2011, she produced festival founder Nancy Buirski's The Loving Story, which premiered at Full Frame and went on to achieve great acclaim, an HBO broadcast and the Academy Award shortlist. James' new film, In So Many Words, also takes the South as its setting, but otherwise it bears little resemblance to The Loving Story.

James is a transplanted Southerner. She studied documentary-making at Stanford before a stint working with prominent filmmaker George Butler (Pumping Iron). She and her husband moved from Brooklyn to Durham four and half years ago. "We were tired of 80-hour work weeks. We were looking for better weather and a better quality of life," she says.

In So Many Words is a striking, often audacious story of a single woman's life, narrated by that woman. With relatively little in the way of archival material, James pursued a strategy of styled, highly idiosyncratic re-enactments and symbolic props, all the while using the subject's insistent, articulate and literate voice-over. And the subject? Lucy Daniels, who began her life as a cloistered daughter of one of Raleigh's most famous families, the one that owned the Raleigh News & Observer. (In her words, the family was "prominent but not proper.")

The film's focus is on Daniels' struggle with severe anorexia, the years she spent in psychiatric institutions, her youthful success as a novelist and her midlife discovery of psychoanalysis. It's that last preoccupation that forms the core of James' film, which finds considerable inspiration in Daniels' memories, dreams, fiction and poetry. "The camera keeps moving, never really settling," says James. "It keeps the audience connected at a subconscious level with Lucy."

It's a documentary that required dramatic structure and production design, and James shares creative input with cinematographer Andreas Burgess and writer Lindsay Devlin, along with her husband Revere La Noue, who served as co-producer and art director. [Disclosure: INDY freelancer Ashley Melzer, who contributed to this section's festival coverage, is an associate producer of In So Many Words.]

While James was still working on The Loving Story, CDS director Tom Rankin introduced her to one of Daniels' children, Patrick Inman (who would serve as consultant). Another offspring, Lucy Noble Inman, became a producer of the film, but James says of the family, "They gave me a wide berth to do as I saw fit. I started by reading Lucy's memoir, and I got to the part about having a memory when she was 20 months old and went, 'Wow!'"

Durham's Phoebe Brush is making her first appearance at Full Frame... with a film, that is. She was a longtime staff member of the fest, eventually becoming programming director, a position she held until 2008. Around the same time, she began work on Yucca Mtn Tally, her 21-minute meditation on nuclear waste and the scale of time. The U.S. Department of Energy planned to store nuclear waste in a facility deep within the 6,700-foot Yucca Mountain, Nev., perhaps a final insult to a region that endured hundreds of underground nuclear explosions. Initially, the facility was designed to hold waste safely for 10,000 years. Brush was struck by this as she considered how long ago 10,000 years was.

"The 'tally' in the film's title refers to a tally stick," she says. It's the oldest known method of recording information with symbols?one that dates back 30,000 years. "That time period is within the scope of the time they're storing the waste," she says.

But the film isn't entirely abstract. Brush speaks to residents of the area?a white man who was exposed to radiation from the underground testing and is now battling cancer, and a Shoshone elder. The violence done to the land has also been done to them.

Nicole Triche's Taxidermists takes a straightforward approach to a quirky subculture?the classic documentary short subject. Two years ago, she visited St. Charles, Mo., for the World Taxidermy and Fish Carving Championship. There, she encountered passionate professionals working at an extraordinary level of craft.

Triche interviewed about 10 taxidermists before settling on Dennis Harris and Wendy Christensen-Senk as her subjects. Harris' piece is the showstopper of her film?a tableau of a moose being attacked by eight wolves. The moose is in mid-stumble, while teeth-baring wolves are clambering over the antlers, flying through the air and sneaking up behind. Meanwhile, Christensen-Senk describes discovering the passion as a child, and learning via correspondence course.

Taxidermists succeeds as a celebration of a fervent subculture, but even here there's a sense of a vocation and passion under threat. Christensen-Senk worries that she won't be replaced when she retires from Milwaukee Public Museum and that digital education and outsourcing will be seen as more efficient.

Triche, whose Full Frame debut was another anatomically themed short, the 2007 short Metacarpus, is an assistant professor at Elon University. The job affords some project money, which she supplemented with her own funds. In the summer of 2012, she edited the film at home while pregnant. (Incidentally, James and Brush also had their post-production schedules complicated by pregnancies. But only Triche's baby was born the day after editing finished, her Full Frame entry safely in the mail.)

Nile Perch, the latest addition to Josh Gibson's Full Frame canon (which includes last year's short, Kudzu Vine, and The Siamese Connection, a feature from 2008 in which?disclosure?my wife Katja Hill appeared), emerged from a workshop he helped lead in Uganda, which was organized by Indian filmmaker Mira Nair. "It was designed to teach Ugandans how to tell their own stories, first of all, but also to give them skills to get crew positions with production companies passing through," Gibson says.

Nile Perch was conceived as a teaching exercise: Follow the life of one fish, from the sea to the plate. The Nile perch is an invasive species that has wiped out most of the indigenous fish in Lake Victoria; it's now central to a notorious fish trafficking industry. But Gibson's interests were less about the social problem (scrutinized at length in the 2004 feature doc Darwin's Nightmare) and more about technical and aesthetic issues. He made the film in six days during spring break from his teaching job at Duke, shooting it on a heavy Cold War-era Soviet 35mm camera he owns, on black and white stock he painstakingly processed in his Durham basement.

"Shooting 35" could become the film version of an indie band recording analog and distributing via vinyl, or a news startup for print (yes, people are still doing those). It's an aesthetic and philosophical choice?the texture of celluloid remains unmatched by the clean, perfect array of HD pixels. But it's also a choice to do things the hard way, as a nod to the "slow" economy that places value on things other than convenience.

Gibson expressed concern, too, that the incredible ease by which images can be acquired, edited and distributed also presents problems for their preservation?which was the subject of a widely discussed report by the Motion Picture Arts and Sciences Academy. "I've encountered this myself," Gibson says. "I've lost footage that I shot years ago. I plug in the drive and it doesn't work. It's all gone."

Although several older docs will receive 35mm screenings, Nile Perch will be the only new documentary to require a film projector at this year's festival.

Other locally oriented films in this year's festival include Will For the Woods, which features a Durham subject in its study of green burial practices. Also, Durham veteran and past Full Frame award winner Rodrigo Dorfman will preview a personal work called Occupy the Imagination at the annual works-in-progress block on Sunday.

This article appeared in print with the headline "Time and memory."

Source: http://www.indyweek.com/indyweek/full-frame-2013-four-fine-documentaries-by-durham-filmmakers/Content?oid=3493134

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